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When you take it orally, your stomach acid and enzymes break down much of it before it ever reaches your bloodstream

The rationale and design across its trials were described by Giblin and colleagues in Diabetes, Obesity and Metabolism in 2026 (PMID 41090431)

Oxeiptosis is mediated by KEAP1, phosphoglycerate mutase family member 5, and apoptosis-inducing factor mitochondrion-associated 1 under oxidative stress [6]